Activated platelets induce hypoxia-inducible factor-1α expression likely through transforming growth factor-β1 in human endometrial stromal cells
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منابع مشابه
Human Leukocyte Antigen-G Expression on Dendritic Cells Induced by Transforming Growth Factor-β1 and CD4+ T Cells Proliferation
Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...
متن کاملHypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1α and inhibits stromal cell-derived factor-1 in human endometrial stromal cells.
BACKGROUND Hypoxia of the human endometrium is a physiologic event occurring during the perimenstrual period and the local stimulus for angiogenesis. The aim of this study was to investigate the effects of hypoxic stress on the regulation of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1/CXCL12), and the potential role of hypoxia-inducible factor-1α (HIF-1α) ...
متن کاملHypoxia-inducible factor-1α activates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts
Hypoxia of local tissue occurs during the scar formation; however, the degree of ischemia and hypoxia in the central areas of keloids is more serious than those in normal scars. Hypoxia-induced factor (HIF), is one of the main cellular responses to hypoxia, allowing cells to adapt to low-oxygen conditions. We investigated the correlation among hypoxia, transforming growth factor-β1/Smad signali...
متن کاملTransforming growth factor β1 enhances adhesion of endometrial cells to mesothelium by regulating integrin expression
Endometriosis is the abnormal growth of endometrial cells outside the uterus, causing pelvic pain and infertility. Furthermore, adhesion of endometrial tissue fragments to pelvic mesothelium is required for the initial step of endometriosis formation outside uterus. TGF-β1 and adhesion molecules importantly function for adhesion of endometrial tissue fragments to mesothelium outside uterus. How...
متن کاملExpression of vascular endothelial growth factor and hypoxia-inducible factor 1α in rat traumatic lung injury
Hypoxia-inducible factor 1α (HIF-1α) is an important transcription factor in mediating oxygen homeostasis that can regulate vascular endothelial growth factor (VEGF) gene transcription. HIF-1α can induce neovascularization in ischemic injury. This research observed HIF-1α and VEGF expression in traumatic lung injury (TLI) to discuss their correlation. Healthy male SD rats at 7-week old were ran...
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ژورنال
عنوان ژورنال: Reproductive and Developmental Medicine
سال: 2019
ISSN: 2096-2924
DOI: 10.4103/2096-2924.262390